Craddock and Mynor-Wallis’s assault on thinking

I have followed this debate (fierce argument) with interest. It has taken place in the British Journal of Psychiatry. It turned my thoughts back to Professor Craddock’s, July 2008, “Wake-up Call for British Psychiatry” which also grabbed my attention (and the attention of many others going by written replies to Craddock et al)

Wake-up call from omphalos on Vimeo.

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The Editorial by Professor Nick Craddock on this occasion was entitled “Psychiatric diagnosis: impersonal, imperfect and important” and was authored along with Laurence Mynors-Wallis. It was published in February of this year
[BJP February 2014 204:93-95; doi:10.1192/bjp.bp.113.133090]. This Editorial may not be open-access, so I will include the full text at the end of this post.

Here is the reply to the Editorial by a group of psychiatrists, including James Rodger, Sami Timimi, Joanna Moncrieff, Graham Behr, Carl Beuster, Pat Bracken, Ivor Browne, Chris Evans, Suman Fernando, Rhodri Huws, Bob Johnson, Navjyoat Kingsnorth, Brian Martindale, Hugh Middleton, Derek Summerfield, Philip Thomas, and Jeremy Wallace.

Craddock1

The robust response by Craddock and Mynors-Wallis, below, only serves to increase the polarisation of this debate. This is not helpful and diverts attention from our shared aim in reducing patient suffering:

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EDITORIAL: Psychiatric diagnosis: impersonal, imperfect and important
Nick Craddock and Laurence Mynors-Wallis

Abstract
Psychiatric diagnosis is in the spotlight following the recent publication of DSM-5. In this article we consider both the benefits and limitations of diagnosis in psychiatry. The use of internationally recognised diagnoses, although insufficient alone, is part of a psychiatrist’s professional responsibility to provide high-quality, evidence-based care for patients.

The place of diagnosis in psychiatry is once again in the spotlight because of the recent publication of the latest revision of the US classification scheme DSM-5.1 Criticisms of DSM-5 include the overmedicalisation of normal experiences,2 the integrity of those involved3 and extend to broader criticisms of the conceptual basis of psychiatric diagnosis4 and even the need for diagnosis at all.5,6 This is a timely moment, therefore, to set out why diagnosis is important in modern psychiatric practice and to be clear about both the benefits and limitations. It is also important to be clear that diagnosis alone is insufficient in conceptualising psychopathology in any individual patient. Diagnosis should be part of a formulation that brings together aetiology, severity and functioning and should lead to a management plan.

Imperfect: there are significant limitations to current classification
All can agree that psychiatric diagnosis is not perfect.7-11 A fundamental issue in psychiatry is that current classification schemes are of clinical syndromes. Diagnosis is based on descriptive data elicited from clinical observation rather than measurements that relate directly to brain function and pathology. This arises because our understanding of the brain, particularly its higher functions, is less well understood than for many other areas of medicine where, of course, far less complex organs are the focus of interest.

It is important to note that there are differences between the DSM classification system (used in the USA) and the ICD system used in the rest of the world. The DSM is underpinned by a research culture that has sought to have diagnoses as homogeneous as possible for the investigation of treatment and prognosis. This inevitably excludes many patients who do not meet strict diagnostic criteria and creates the need for multiple ‘comorbid’ diagnoses when, for example, patients with a depressive disorder are also diagnosed as having a range of anxiety disorders. The problem has been stated amusingly and clearly by Dr Steve Hyman, a former Director of the National Institute of Mental Health: ‘DSM… has the miraculous bad property of being too broad and too narrow at the same time’ (cited in Aldhous & Coghlan).12 The ICD has always been more pragmatic by being less rigid about diagnostic criteria. It facilitates sensible clinical diagnoses but at the expense of including within the categories more heterogeneous patient groups.

Psychiatrists should not be defensive that the diagnostic categories alter over time – this is no different to alterations in the definition of, for example, hypertension and diabetes. Also, as with hypertension and diabetes, many of our disorders represent an extreme of variation within the population. And, as for blood glucose level or diastolic blood pressure, this does not mean that the extremes do not cause significant problems for individuals or that they do not require careful assessment and treatment.

Impersonal: diagnosis alone is not sufficient
The higher functions of the brain are complex and reflect the interplay of diverse processes from the molecular to the social. It is, therefore, natural to expect that brain dysfunctions will reflect this rich complexity and defy simple, reductionist models (be they molecular, psychological, social or any simplistic admixture). To most psychiatrists, this is one of the great appeals of the specialty – the challenge of helping a patient by embracing complexity and using pragmatism to guide the help that we provide. A good psychiatrist (as any good doctor) must be aware of the limitations of the diagnostic categories used and decisions made. It is important to think beyond diagnosis and make assessments of causation, the range and pattern of symptoms, severity and impairment in functioning (sometimes called ‘domains of psychopathology’13). The key is to produce a formulation that goes beyond a simple list of facts and that complements the diagnosis by including information about important clinical variables that have relevance for the management plan. So for bipolar disorder, this might include such variables as the lifetime preponderance of mania v. depression, tendency to develop suicidal ideation, lifetime experience of psychotic features, inter-episode functioning (including cognitive), co-occurrence of panic/anxiety, co-occurrence of alcohol and substance misuse, history of triggering of mood instability by antidepressants, etc. Together with assessments of the patient’s life circumstances, relationships, experiences and personality, these detailed clinical assessments feed into the formulation and management plan.

Important: diagnosis is a key component of high-quality, safe care
Diagnosis is a key part of how we communicate with our patients and each other.14 Indeed, in any situation in which more than one intervention is available some form of classification/diagnosis is needed to guide logical decisions about which intervention is better (or whether no intervention is the optimal option). If an adult presents with lethargy, weight loss, reduced activity and reduced interested in life, we need to distinguish between such diverse possibilities as (a) temporary adjustment to a changing life situation (i.e. understandable normal response to life’s difficulties), (b) cancer, (c) heart failure, (d) severe depressive episode with immediate risk of suicide. Diagnosis is a key to determining which interventions will be of value and underpins the entire opus of evidence-based practice.

The importance of diagnosis for patients is growing rather than decreasing.14 A diagnosis provides reassurance that their situation is not unique, mysterious or inexplicable and that there is a body of knowledge and experience that can be brought to bear in providing help. A diagnosis can help reduce inappropriate feelings of blame (perhaps parents believing that their parenting is at fault in a child diagnosed as having autism). It can reduce stigma by explicitly acknowledging the presence of illness (and, thus, that the feelings or behaviour cannot be dismissed as character weakness or bloody-mindedness). Diagnosis can help an individual make sense of being different or of not functioning like most others and challenges the feelings of shame, loneliness and low self-esteem that may otherwise occur if they are simply treated as being ‘odd’, ‘bad’ or having a ‘character flaw’. Diagnosis helps to communicate information between public and professionals about the support and service needs (including, where needed, speech and language therapy, occupational therapy, schooling support, etc). Diagnosis allows patients and carers to talk with, and get advice from, people with similar problems (for example, through support organisations such as UK Bipolar), advocate for improved services for particular groups of patients, (for example, the recent Schizophrenia Commission report15) and be able to read the most relevant educational and self-help material. Individuals and families may actively seek to be diagnosed with certain diagnoses such as Asperger syndrome as a way of both helping them to understand themselves and also seek therapeutic interventions.

Psychiatric and non-psychiatric illness
It is important to be clear that there are no issues about diagnosis (or indeed treatments) that are unique to psychiatry.7 As psychiatrists we have a tendency to be more reflective and tolerant of strongly opposing views and ideologies than in many other medical specialties and spheres of human endeavour (and, indeed, more tolerant than among some non-medical professions within mental health). This can be to our patients’ disadvantage if we allow these views to be unopposed by suggesting that our patients are somehow less deserving of a psychiatric diagnosis than a physical diagnosis if for example they had broken their leg. Despite the caveats we have given, using operational diagnostic classifications psychiatrists can make diagnoses more reliably than cardiologists diagnosing myocardial infarction based on clinical assessment.16 Of course, what psychiatry awaits is specific tests, such as electrocardiograms and cardiac enzymes, that cardiologists use to confirm or refute diagnoses based on clinical assessment alone. For all the well-recognised limitations of operational diagnostic categories, many define highly heritable clinical entities that have allowed the identification of risk genes that provide a clue to understanding pathophysiology.13 Further, in psychiatry we have many treatments that have been developed and tested against diagnoses that compare very favourably in efficacy with those for non-psychiatric illnesses.17

Improvements: into the future
We can certainly expect that over the coming generation psychiatry will move towards a classification that is better informed by understanding of the normal and abnormal workings of the brain.11,13,18 The current Director of the National Institute for Mental Health (NIMH), Dr Tom Insel, has made explicit that future NIMH-funded research will need to use approaches that are based on domains of psychopathology rather than DSM categories.19 He said that the long-term future for mental health is in the detection of biomarkers and that diagnosis should be informed by objective laboratory measures. The future is likely to require a willingness to use both categorical and dimensional approaches. It will also be necessary to ensure consistency between the diagnoses used in all aspects of medicine that relate to brain and behavioural disorders.20 Further, like all medical classifications, it is likely to involve a pragmatic mix of approaches that reflect the differing levels of understanding of each diagnostic entity.9

Will the approach in 50 years’ time look like DSM and ICD do today? Almost certainly not. Advances in understanding of neuroscience and other disciplines relevant to psychiatric disorders are likely to lead to diagnostic systems that map much more clearly onto the functions and dysfunctions of the brain.

Pragmatism: the professional, practical and patient-focused approach
So, what should we, as practising clinical psychiatrists, do now? We need to be pragmatic, thoughtful and honest. As we have discussed, there are a variety of limitations and shortcomings of current diagnostic schemes in psychiatry (as there are for classifications in other areas of medicine). We must recognise and acknowledge these and the need to be working towards better approaches in the future. However, we must use the tools for communication, evidence evaluation and decision-making that are currently available – namely the internationally recognised operational classifications. We must use these in a manner that maximises their benefits while minimising their disadvantages. We should continue to make diagnoses complemented by formulations in which a range of additional factors are brought together that are relevant to management and prognosis.

Conclusion
When used well, diagnosis is a key to assisting patients in making informed decisions about their care. It can ensure a patient gets effective help as quickly as possible and can benefit from the body of knowledge that has been built up from those who have had similar experiences previously. Most people who seek help from mental health professionals want these benefits. When a patient consults a psychiatrist they have a right to expect an expert diagnostic assessment and the psychiatrist has a professional responsibility to provide such an assessment and use it to guide available evidence-based treatments. See, for example, the Royal College of Psychiatrists’ Good Psychiatric Practice21 in which diagnosis is mentioned on six occasions and which provides absolute clarity about the necessity for a psychiatrist to be able to use diagnosis effectively as a tool for communication and decision-making. For example:

‘Good psychiatric practice involves providing the best level of clinical care that is commensurate with training, experience and the resources available. It involves the ability to formulate a diagnosis and management plan based on often complex evidence from a variety of sources.’ (p. 9)

‘In making the diagnosis and differential diagnosis, a psychiatrist should use a widely accepted diagnostic system.’ (p.10)

This is not an issue of personal choice for a practitioner. It is a professional responsibility to the patient.

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