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By Hole Ousia Posted on September 29, 2014January 14, 2023

Early detection of dementia: RCPsych result

“This House supports the early detection of dementia” Following on from my previous post which outlined my opposing argument, I can now share the result of this RCPsych debate: The … Continue reading Early detection of dementia: RCPsych result

Categories: Alzheimer's disease, Dementia, Neuro-imaging, NHS Hospitality Registers, Pharmaceutical industry and Medical Education, Sunshine Act for ScotlandTags: "Toxic certainty" - Alzheimer's Society, 'King of Lewy Body research', 'The Edinburgh Consensus: Preparing for the advent of disease-modifying therapies for Alzheimer's disease' Alzheimer's research & therapy, 2014, A 24-week, a blot a stain or perhaps something worse, A rallying call for an evidence based approach to dementia ‎and related policy, A rallying call for an evidence based approach to dementia ‎and related policy development, A Sunshine Act for Scotland, A timely arrival, acetyl-cholinesterase inhibitors are not disease modifying, acetylcholinesterase inhibitors, advocated the pre-diagnosis of dementia, ageing brain, ageism, Alistair Burns, All-Party Parliamentary Group on Dementia, All-Party Parliamentary Group on Dementia. How to improve dementia diagnosis rates in the UK, ALZ1906, ALZ1907, Alzheimer, Alzheimer Scotland, Alzheimer Society, Alzheimer Society film: Dementia Ambassador, Alzheimer's, Alzheimer's disease, Alzheimer's from the inside out, Alzheimer's Society, Alzheimer’s drugs ‘overprescribed’ suggest NHS figure, Alzheimerisation, Alzheimerisation of society, amyloid, Amyloid imaging to prevent Alzheimer's disease, AMYPAD, AMYVID, an underestimation by analysts of the number of people with Alzheimer’s disease, and Cost of Physicians' Prescribing: A Systematic Review, anti-amyloid drugs, anti-dementia, anti-dementia drugs, Antiquary, at risk, ‘Evidence Based Medicine’ or ‘Industry Biased Medicine’, “Anti-dementia” drugs improve the outcome, Back in the driving seat, Bad Medicine, Bad Medicine: dementia, Baroness Cumberlege, barriers to evidence-based prescribing in Alzheimer’s disease, BBC news, Big Pharma, Bioscience's Promethean Promises of the new biology, BMJ, BMJ 2013;347:f5597, BMJ 2014;348:g2607, branding, branding firm, British Journal of General Practice, by putting clinicians in the driving seat of any clinical ‎assessment will protect individuals against any inappropriate intervention, Cambridge Cognition, CANTAB mobile, CANTABmobile and its misleading promotion, Cart or Horse, case-finding, case-finding and screening, Chan M. WHO director-general addresses G8 dementia summit., Chief Executive of the Mental Welfare Commission for Scotland, Chief Executive Officer of IXICO, Classic Pharma shill stuff, Clive Ballard, Cognitive Impairment: Do you have the evidence you need to reach a diagnosis?, competing interests, Complete Clarity, Complexity and dementia, Conditions and Diseases, Conference, Confusion is everywhere, Consent, Continuing Medical Education and its entanglement with the Pharmaceutical Industry, Cumberlege Review, current treatments only help with symptoms for a short while, David Cameron, Delphi figures, Dementia, dementia ambassador, Dementia case-finding: language and ethics, dementia challenge, Dementia DES, Dementia DES will result in widespread misdiagnosis, dementia guidelines, Dementia Guidelines: research and clinical criteria are not simply “interchangeable”, Dementia Policy, dementia prevalence calculator, Dementia Tsar, Dementia: the “epidemic” of metaphors, Dementia: who is in the “driving seat, Derek Hill, Des Spence, disease mongering, do prescribe the “anti-dementia” drugs, Do we care enough about consent?, Does early diagnosis really save lives?, double-blind, double-blind study of donepezil in moderate to severe Alzheimer’s disease, Dr Iona Heath, Dr Jill Rasmussen, Dr Peter Gordon, Driving Sea, Driving Seat, Drug Discovery Programme - Alzheimer's Society Dementia Research, DSM5 Minor Neurocognitive Disorder, Durham, Early detection of dementia: RCPsych result, early diagnosis, early diagnosis is crucial to end “toxic uncertainty” for both patient and family, early diagnosis is everywhere, Early diagnosis of Alzheimer’s disease, early diagnosis of dementia, Edinburgh, Edinburgh Consensus, Effects of memantine on cognition in patients with moderate to severe Alzheimer’s disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, Eli Lilly, Eli Lilly UK, EPAD, epidimiology, ethicists, ethics, European ALCOVE project, European Prevention of Alzheimer's Dementia Consortium, evidence, explaining to my patients that this is because they may produce mild symptomatic improvements in the short term, false positives, Fiona Phillips., first do no harm, FOI returns, From forgetfulness to dementia: clinical and commissioning implications of diagnostic experiences, fully informed consent, future-focussed market landscape, G8 dementia summit, G8 summit, Genes Cells Brains, Geoff Huggins, Glasgow Declaration, Good Medical Practice, Good news on dementia prevalence – we can make a difference., Government backs new high tech early dementia assessment service to reduce time to diagnosis from 18 months to 3 months, harm, he full spectrum of ethical issues in dementia care: systematic qualitative review, he paradigmatic brain pathology of Alzheimer’s Disease – plaques and tangles – is only a post-mortem finding of limited explanatory value in the expression of dementia in the population, Health & Social Care Information Centre, HEAT target 4, Hilary and Steven Rose, Hole Ousia, Hope over dementia summit boost to ailing industry, House of Commons, How much is too much medicine, How to improve dementia diagnosis rates in the UK, How we risk getting it wrong in cognitive screening too, Human Rights, imaging, Improvement in behavioural symptoms in patients with moderate to severe Alzheimer’s disease by memantine: a pooled data analysis, In Defence of Wonder (And other philosophical reflections), in terms of a cure, In the driving seat, In this published reply no declarations of interest were made., independent experts or drug representatives in disguise, industry, Industry's interest in diagnosing dementia, Information from Pharmaceutical Companies and the Quality, informed consent, interests, Inverse care, Issues around early diagnosis of Alzheimer’s disease, Issues not considered in the 'Edinburgh Consensus', IXICO has worked with seven of the top fifteen pharmaceutical companies, IXICO: we put patients at the heart of what we do, J Haynes, Jeremy Hunt, Jesse Ballenger, Key Opinion Leaders, Key opinion leaders: independent experts or drug representatives in disguise?, Kill the QOF, Lancet, LCOVE: a European Joint Action on Alzheimer’s disease, lived experience, Long-term Donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial, Lunbeck, Lundbeck, Many of these Key Opinion Leaders are today still being well paid for educating us all, Mapping the Future of Alzheimer’s Disease: The Business Problem, maps, Margaret Chan, Martin Brunet, Mary Midgley, MCI, Medical Diagnostics, Medical Sociology and Old Age: Towards a sociology of health in later life., medication, mental Welfare Commission, mild cognitive impairment, Mini–mental state examination, misdiagnosis, modifying, Motion defeated, My argument against the motion, My reply to Tripathi and Kumar, Narrative Controllers, National Clinical Director for Dementia, National Dementia 2014 Conference, Neurological Disorders, NHS Scotland, NICE, NICE guidance, NICE guideline 42 (updated), no competing declarations, No sunshine for Scotland, Northern and Yorkshire Autumn Conference of the Royal College of Psychiatrists, Nuffield Council on Bioethics, old age psychiatrist, On the Map, Only now, only when off-patent, Open letter to the prime minister and chief medical officer for England: There is no evidence base for proposed dementia screening., or even a treatment that can modify the disease we are empty-handed, outcome, Outcome of judicial review for NICE guidance on drugs for Alzheimer's disease., over-diagnosis, overdiagnosis, Overdiagnosis: when good intentions meet vested interests, paid opinion leaders, paid opinion leaders are a blot on medicine’s integrity and we should make them a thing of the past, parabolic distribution, paradigm shift, paradigmatic, PE1493, PE1517, Peter Gordon, Peter J Gordon, Peter's Lost Marbles, pharma, Pharmaceutical Industry, placebo controlled studies, plaques, plaques and tangles, Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis, Polypropylene Mesh Medical Devices, Post-diagnostic support, pre-diagnosis of dementia, preclinical, preclinical Alzheimers, preclinical dementia, prevention, Primum non forgetful, Principles and Practice of Screening for Disease. World Health Organisation, Probity, prodromal, prodromal dementia, Professor Alistair Burns, Professor Alistair Burns considers that I may have taken the wrong direction by expressing concerns about bias introduced by vested commercial interests, Professor Carol Brayne, Professor Clive Ballard, Professor Sube Banerjee, prognosis, Progressive Test, Promises of transparency? Hold the applause, Proposed dementia screening: Confusion is everywhere, public health, PULSE magazine, Putting dementia on the map, Quantity, randomized, Raymond Tallis, RCPsych, Realistic Medicine, rebel antiquary, rebranding psychiatry, Rees Jones, Reply by Tripathi and Kumar, research, research criteria, Reward doctors for early diagnosis of dementia, Richard Taylor, Ritchie Consultancies Ltd, Robert K Merton, room 101, Royal College of Psychiatry, says think tank, scientific pluralism, Scientists want G8 countries to quadruple funding for dementia research within 10 years, Scottish Government, screening, Screening and case-finding are one and the same thing, Senility, Shrink rethink: rebranding psychiatry, SIGN 86 Guideline, Simone de Beauvoir, snakes ladders and Monopoly, Social maverick, Social Structure and Anomie, stigma, Sunshine Act, Sunshine Act for Scotland, swayed by the determination of a "Paid Opinion Leader", tangles, Target Diagnosis Rates - a New Mechanism for Overdiagnosis?, target-driven, target-driven activities, target-driven medicine, targets, Tau Therapeutics, The Alzheimer’s Hockey Stick, The Antiquary, The BMJ’s stance on collaboration with industry, The Cognitive Function and Ageing Study (CFAS) I and II, the death of old age, the diseased other, The Edinburgh Consensus, The Evolving classification of dementia: placing the DSM-V in a meaningful historical and cultural context and pondering the future of “Alzheimers”, The featured image (above) is from the Alzheimer's Society and is their position statement on current anti-dementia medications, The forgetfulness of others, The Glasgow Declaration, The medical untouchables, The Myths we Live By, The Narrative Controllers, the paradigmatic brain pathology of Alzheimer’s Disease – plaques and tangles – is only a post-mortem finding of limited explanatory value in the expression of dementia in the population, The patient paradox, the Prime Minister's Challenge on Dementia, The Rebel Antiquary, The report of the Independent Medicines and Medical Devices Safety Review, the result of the debate, the summit is reached, The [generally hidden] place of big business, This House supports the early detection of dementia, This story seems to reveal that my profession was perhaps not following evidence but rather wishful thinking and indeed mythology, Through the amyloid gateway, Timely debate, timely diagnosis, timely diagnosis of dementia, to prevent Alzheimer's disease, Too much Medicine, Transparency, Tripathi, Truth telling and dementia, Unlocking Diagnosis, urrent treatments don’t stop dementia from progressing, Use of NICE appraised medicines in the NHS in England, waiting lists, wandering wondering and worrying, was not irrational in concluding that there is no cumulative benefit to patients after 6 months treatment with these drugs, we have had twelve different categories for mild cognitive change in the later years of our life, we will be making a prognosis not a diagnosis, What do we mean by Alzheimer's disease, Who were the biggest winners and losers of the G8 dementia summit?, why ethics matters to us all, Why I feel angry - not grateful - after David Cameron’s dementia summit, widespread misdiagnosis, Wilson and Junger, Wilson and Jungner, windfall of elders, World Alzheimer Report 2011, Wrong Direction

By Hole Ousia Posted on April 17, 2014January 13, 2023

“Anti-dementia” drugs

This letter, by me, was published in the BMJ on the 7 April 2014: This is a BMJ rapid-response reply by Assistant Professor Shailendra Mohan Tripathi Ambrish Kumar, Department of … Continue reading “Anti-dementia” drugs

Categories: Alzheimer's disease, British Medical Journal, Dementia, History of medicine, Medical Education, Medical writings, Pharmaceutical industry and Medical Education, PsychiatryTags: A 24-week, acetylcholinesterase inhibitors, Alzheimer Society film: Dementia Ambassador, Alzheimer's, Alzheimer's Society, anti-dementia, Antiquary, “Anti-dementia” drugs improve the outcome, BMJ, BMJ 2014;348:g2607, Chan M. WHO director-general addresses G8 dementia summit., current treatments only help with symptoms for a short while, Dementia, dementia ambassador, do prescribe the “anti-dementia” drugs, double-blind, double-blind study of donepezil in moderate to severe Alzheimer’s disease, Effects of memantine on cognition in patients with moderate to severe Alzheimer’s disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, explaining to my patients that this is because they may produce mild symptomatic improvements in the short term, Fiona Phillips., G8 dementia summit, Hole Ousia, Improvement in behavioural symptoms in patients with moderate to severe Alzheimer’s disease by memantine: a pooled data analysis, Lancet, Long-term Donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial, Margaret Chan, Mary Midgley, medication, modifying, My reply to Tripathi and Kumar, NICE, NICE guidance, only when off-patent, outcome, Outcome of judicial review for NICE guidance on drugs for Alzheimer's disease., Peter Gordon, placebo controlled studies, randomized, Realistic Medicine, rebel antiquary, Reply by Tripathi and Kumar, Scientists want G8 countries to quadruple funding for dementia research within 10 years, Social maverick, The Antiquary, The Myths we Live By, The Rebel Antiquary, Tripathi, was not irrational in concluding that there is no cumulative benefit to patients after 6 months treatment with these drugs, What do we mean by Alzheimer's disease, Who were the biggest winners and losers of the G8 dementia summit?

By Hole Ousia Posted on April 3, 2014January 13, 2023

Only now

The featured image (above) is from the Alzheimer’s Society and is now their position statement on current anti-dementia medications. More than three months have now passed since the G8 dementia summit … Continue reading Only now

Categories: Alzheimer's disease, Dementia, History of medicine, Medical Education, NHS Scotland, PsychiatryTags: A 24-week, acetylcholinesterase inhibitors, Alzheimer Society film: Dementia Ambassador, Alzheimer's, Alzheimer's Society, anti-dementia, anti-dementia drugs, Antiquary, “Anti-dementia” drugs improve the outcome, BMJ, BMJ 2014;348:g2607, Chan M. WHO director-general addresses G8 dementia summit., current treatments only help with symptoms for a short while, Dementia, dementia ambassador, do prescribe the “anti-dementia” drugs, Do we care enough about consent?, double-blind, double-blind study of donepezil in moderate to severe Alzheimer’s disease, Effects of memantine on cognition in patients with moderate to severe Alzheimer’s disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, explaining to my patients that this is because they may produce mild symptomatic improvements in the short term, Fiona Phillips., fully informed consent, G8 dementia summit, Hole Ousia, Improvement in behavioural symptoms in patients with moderate to severe Alzheimer’s disease by memantine: a pooled data analysis, in terms of a cure, Lancet, Long-term Donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial, Margaret Chan, Mary Midgley, medication, modifying, My reply to Tripathi and Kumar, NICE, NICE guidance, Only now, only when off-patent, or even a treatment that can modify the disease we are empty-handed, outcome, Outcome of judicial review for NICE guidance on drugs for Alzheimer's disease., Peter Gordon, placebo controlled studies, randomized, Realistic Medicine, rebel antiquary, Reply by Tripathi and Kumar, Scientists want G8 countries to quadruple funding for dementia research within 10 years, Social maverick, The Antiquary, The featured image (above) is from the Alzheimer's Society and is their position statement on current anti-dementia medications, The Myths we Live By, The Rebel Antiquary, This story seems to reveal that my profession was perhaps not following evidence but rather wishful thinking and indeed mythology, Tripathi, urrent treatments don’t stop dementia from progressing, was not irrational in concluding that there is no cumulative benefit to patients after 6 months treatment with these drugs, What do we mean by Alzheimer's disease, Who were the biggest winners and losers of the G8 dementia summit?

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